List of Suggested Supplements* Per Patient Reported-Outcomes
Explore our curated selection of supplements, chosen based on real patient experiences and supported by scientific research. We’ve included detailed information on each supplement, including recommended dosages, potential benefits in fighting cancer, and links to purchase. Empower yourself with knowledge and take an active role in your health.
Beta-alanine is an amino acid that may help improve muscle endurance and reduce fatigue, which can be beneficial for cancer patients experiencing treatment-related exhaustion.
Beta-alanine increases muscle carnosine levels, which helps buffer acid buildup in muscles, reducing fatigue. Some research suggests it may support physical performance, but its role in cancer symptom management remains under investigation.
- .VEGAN CAPUSLES: Provides endurance for hard workouts and are proven to delay muscle fatigue.*
- SUGGESTED USAGE: Suggested use is 3 capsules taken with water or your favorite NOW Sports drink up to 2-3 times daily with a two hour window in between doses.
- GMP Quality Assured: NPA A-rated GMP certification means that every aspect of the NOW manufacturing process has been examined, including our laboratory/testing methods (for stability, potency, and product formulation).
- Packaged in the USA by a family owned and operated company since 1968.
- PROs Reported Dosing
- Beta-alanine has most often been used by adults in doses of 1.6-6.4 grams by mouth daily for up to 12 weeks
β-Alanine intercede metabolic recovery for amelioration of human cervical and renal tumors – In summary, experimental data suggest that β-alanine may be a potential anti-tumor agent exhibiting several anti-cancer effects in renal and cervical tumor cells.
Bromelain is an enzyme extracted from pineapples, known for its anti-inflammatory properties. It may aid digestion and reduce inflammation, potentially benefiting cancer patients experiencing treatment-related side effects.
Bromelain assists in breaking down proteins and has been studied for its potential to reduce inflammation and swelling. It may also enhance the absorption of certain medications, though more research is needed in the context of cancer treatment.
- Bromelain is a proteolytic enzyme derived from the stem of the pineapple plant that has protein-digesting properties*
- When taken with food, bromelain can help to support healthy digestion; when taken between meals, it may help to support joint comfort and may help to relieve temporary soreness that is associated with muscle overuse*
- Bromelain is designed by nature to support proper gastrointestinal function and may also help to promote the comfort of muscles and joints*
- Take 1 capsule 1 to 2 times daily, with or between meals
- Packaged in the USA by a family owned and operated company since 1968.
- PROs Reported Dosing
- 80–400 milligrams per serving, two to three times daily.
- Brain Tumor Cleared
https://wholehealthoncology.com/node/51106
- Beneficial Properties of Bromelain – Summarizes extensive research into direct anticancer effects of bromelain, including for breast, ovarian, lung, melanoma, leukemia, and digestive system cancers.
- Bromelain: a review of its mechanisms, pharmacological effects and potential applications – “The anti-cancer activity of bromelain is via induction of apoptosis, inhibition of angiogenesis, and enhancement of the body’s immune response
- Bromelain: A Potent Phytomedicine – “Bromelain also encourages apoptotic cell death and exhibits some anti-cancerous properties.”
Calcium is essential for bone health, and supplementation may be necessary for cancer patients, especially those at risk of osteoporosis due to treatment.
Calcium supports bone density and strength. Combining calcium with vitamin D enhances absorption and effectiveness.
- Suggested use: Adults – One tablet twice daily with food as a dietary supplement. Not formulated for use by children.
- Bone health*
- Vitamin D3 to assist in the absorption of calcium*
- No artificial flavors, gluten, lactose
- Adequate calcium throughout life, as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis in later life.
- Vitamin D3 may help the body absorb calcium and is known for its beneficial effects on strong healthy bones.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- PROs Reported Dosing
- 500-1500 mg calcium taken with 200-1000 IU vitamin D.
- https://wholehealthoncology.com/node/51298
- https://wholehealthoncology.com/node/51276
- https://wholehealthoncology.com/node/51055
- The Effect of Calcium plus Vitamin D on Risk for Invasive Cancer: Results of the Women’s Health Initiative (WHI) Calcium Plus Vitamin D Randomized Clinical Trial – “Calcium/vitamin D supplementation did not reduce invasive cancer incidence or mortality. Supplementation lowered cancer risk in the WHI healthy diet trial arm and in women without a first-degree relative with cancer”
- Calcium supplements and cancer risk: a meta-analysis of randomized controlled trials – “The meta-analysis of patient-level data showed similar results, with no effect of Ca on the risk of total cancer (hazard ratio 1·07, 95% CI 0·89, 1·28, P= 0·50). Ca supplements without co-administered vitamin D did not alter total cancer risk over 4 years”
- Long-Term Effect of Randomization to Calcium and Vitamin D Supplementation on Health in Older Women : Postintervention Follow-up of a Randomized Clinical Trial – “Calcium and vitamin D supplements seemed to reduce cancer mortality and increase CVD mortality after more than 20 years of follow-up among postmenopausal women.”
- Calcium supplementation in clinical practice: a review of forms, doses, and indications – “The risk of advanced and fatal prostate cancer has been associated with calcium intakes from food or supplements in amounts >1500 mg/d.”
Cayenne pepper contains capsaicin, which may offer various health benefits, including pain relief and improved circulation.
Capsaicin is known for its potential to reduce pain by desensitizing nerve receptors and may have anti-inflammatory effects.
- Potent Cayenne Formulation: Delivers a potent 1,500mg of Cayenne Pepper extract (10:1 ratio) per vegetarian capsule, providing a concentrated source of this powerful herbal ingredient.
- Generous Supply: Contains 350 veggie capsules, offering a substantial 350-day supply for convenient and long-lasting use.
- Vegan-Friendly and Gluten-Free: Formulated as a vegan and vegetarian-friendly supplement, free from gluten to accommodate various dietary preferences.
- Quality Manufacturing: Produced in a cGMP-registered facility adhering to rigorous manufacturing and sourcing standards, ensuring quality and purity.
Capsaicin: From Plants to a Cancer-Suppressing Agent – “Additionally, it has been found that capsaicin can act as a cancer preventive agent and shows wide applications against various types of cancer.”
Curcumin, the active compound in turmeric, has anti-inflammatory and antioxidant properties. Liposomal formulations may enhance its absorption and effectiveness.
Curcumin modulates various molecular pathways involved in inflammation and cell growth. Liposomal delivery systems improve its bioavailability.
- Potent Turmeric Blend: Boasting 1950mg of premium turmeric curcumin complex, with 95% standardized curcuminoids for maximum efficacy.
- Enhanced Absorption: Fortified with BioPerine (black pepper extract) to improve the bioavailability and absorption of turmeric’s beneficial compounds.
- Trusted Quality: Manufactured following strict cGMP guidelines and third-party tested to ensure purity and potency in every batch.
- Vegan-Friendly Formula: A natural, non-GMO, and vegan supplement suitable for various dietary preferences.
- PROs Reported Dosing
By itself, curcumin is poorly absorbed. It is usually paired with piperine (a black pepper extract) or compined with lipids (BCM-95, Meriva …). To supplement curcumin with piperine, take 500 mg of the former with 5-6.7 mg of the latter, thrice a day (i.e., 1,500 mg of curcumin and 15-20 mg of piperine per day).To supplement BCM-95, a patented combination of curcumin and essential oils, take 500 mg twice a day (i.e., 1,000 mg/day). To supplement Meriva, a patented combination of curcumin and soy lecithin, take 200–500 mg twice a day (i.e., 400–1,000 mg/day). Curcumin is usually taken together with food.
- https://wholehealthoncology.com/node/51122
- https://wholehealthoncology.com/node/51106
- https://wholehealthoncology.com/node/51092
- https://wholehealthoncology.com/node/51496
- Curcumin and Cancer– “Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.”
- Changes in Lysine Methylation Contribute to the Cytotoxicity of Curcumin in Colon Cancer Cells – “Interestingly, curcumin also reduced mutp53 expression, suggesting that it could enhance the efficacy of other therapies, particularly in overcoming drug resistance mechanisms associated with mutp53”
- Re-Sensitization of Resistant Ovarian Cancer SKOV3/CDDP Cells to Cisplatin by Curcumin Pre-Treatment – “This current study could deepen our understanding of the anticancer mechanism of CUR pre-treatment, which not only facilitates the re-sensitization of ovarian cancer cells to cisplatin but may lead to the development of targeted and effective therapeutics to eradicate SKOV-3/CDDP cancer cells.”
Essiac tea is an herbal blend that some individuals use as a complementary approach to support overall health.
Comprising herbs like burdock root, sheep sorrel, slippery elm, and Indian rhubarb, Essiac tea is believed to possess antioxidant and anti-inflammatory properties. While anecdotal evidence suggests benefits, scientific validation is limited.
- Manufacturers of the product recommend drinking 1 to 12 ounces (30 to 360 mL) daily for best results.
- Inhibition of prostate cancer-cell proliferation by Essiac – “Essiac preparations may be able to inhibit tumor cell growth while enhancing immune response to antigenic stimulation.”
- Remission of hormone-refractory prostate cancer attributed to Essiac – “Described here the case of a 64-year-old man whose hormone-refractory prostate cancer responded well to Essiac tea.”
Essiac Tea
Frankincense extract is utilized for its anti-inflammatory effects, particularly in joint health and respiratory conditions.
Active compounds inhibit 5-lipoxygenase, an enzyme involved in leukotriene formation, which are mediators of inflammation. This inhibition can reduce inflammation and alleviate symptoms in conditions like osteoarthritis and asthma.
- Frankincense has been traded on the Arabian Peninsula and in North Africa for more than 5000 years. It has a wide variety of uses ranging from Aromatherapy to Skincare
- Frankincense oil has been praised for its calming & relaxing nature that relaxes tensed state of the mind and body. A simple head and body massage or aromatherapy session with this oil is ideal for increasing relaxation and elevate mood
- The warm, wood-like and menthol-like aroma of the frankincense oil makes it a perfect choice for use in aroma diffusers and ultrasonic humidifiers to fill the interiors with a calming aroma that lingers in the mind for hours. Perfect for diffusing in the home, office, aromatherapy centres and clubs. Either diffuse a few drops of this miraculous oil in an ultrasonic humidifier or put 4-5 drops in warm water and inhale the evolving vapors.
- Natural, Unfiltered, Undiluted, No Toxins, No Additives, No Preservatives, Packaged in the USA, Cruelty Free Product, Not Tested on Animals- Leaping Bunny Program Certified
- Manufactured in US Organic’s own GMP-certified and USDA certified facility where meets or exceed all municipal and government standards.
- PROs Reported Dosing
- Typical frankincense dosages range from 300-3,600 mg per day.
- Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities – “Frankincense modulates signaling transduction responsible for cell cycle arrest and inhibition of proliferation, angiogenesis, invasion and metastasis… Frankincense revealed beneficial effects towards brain tumor-related edema, but did not reduce glioma size. Even if there is no treatment effect on brain tumors itself, the management of glioma-associated edema may represent a desirable improvement.”
- Synergistic Enhancement of Carboplatin Efficacy through pH-Sensitive Nanoparticles Formulated Using Naturally Derived Boswellia Extract for Colorectal Cancer Therapy – Frankincense nanoparticles enhanced apoptosis of colorectal cancer cells in combination with carboplatin.
- Chemical Constituents and Pharmacological Properties of Frankincense: Implications for Anticancer Therapy – “Frankincense and its principal chemical constituents have demonstrated promising chemoprophylactic and therapeutic abilities against tumors.”
Fulvic acid is taken to enhance nutrient absorption, support detoxification, and improve energy levels.
As a natural compound found in soil and organic matter, fulvic acid enhances nutrient uptake by forming complexes with minerals, facilitating their transport into cells. It also exhibits antioxidant properties and may aid in detoxifying pollutants.
- Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid: BAX/BCL-2 and Tyr genes expression and evaluation of nanomechanical properties in A375 human melanoma cell line – Fulvic acid induces apoptosis in melanoma cells.
- Fulvic acid promotes extracellular anti-cancer mediators from RAW 264.7 cells, causing to cancer cell death in vitro – Fulvic acid induces apoptosis in liver, prostate, and leukemia cells.
- Fulvic Acid Attenuates Resistin-Induced Adhesion of HCT-116 Colorectal Cancer Cells to Endothelial Cells – Fulvic acid may impair development of colorectal cancer by inhibiting adhesion of cancer cells to healthy tissue.
Fulvic Acid
Glutathione is a potent antioxidant that protects cells from oxidative damage. Liposomal forms aim to improve its bioavailability.
Glutathione neutralizes free radicals and supports detoxification processes. However, oral supplementation often faces absorption challenges. Liposomal encapsulation enhances its stability and absorption, increasing systemic availability.
- 60 capsules, a 2 month supply (taken daily at the listed serving size)
- Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
- No artificial colors or flavors; no chemical preservatives; no binders (additional ingredients used as flow agents to aid in manufacturing); vegan; gluten free; Star K kosher certified
Purpose
- Consisted of 2.2% of Iodine & 4.4% of Iodide in demineralized water. Pharmaceutical grade ingredients.
- Each vertical drop is about 2.772 mg’s of iodine and potassium iodide – (1.1 mg iodine and 1.672 mg potassium iodide).
- No need to refrigerate, but keep out of direct sunlight.
- https://wholehealthoncology.com/node/51122
- https://wholehealthoncology.com/node/51158
The Impact of Iodine Concentration Disorders on Health and Cancer – Lugol’s iodine was reported to inhibit growth of breast cancer cells.
Purpose
- Suggested use: Adults – Dissolve one tablet daily under tongue for 30 seconds, then swallow. Use just prior to or at bedtime.
- May help support restful sleep*
- No artificial flavors, gluten or lactose
- Dye-free
- Melatonin is a naturally occurring compound that is produced by the body. It has been associated with normal body rhythms and sleep/wake patterns.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
- PROs Reported Dosing
- Melatonin has most often been used by adults in doses up to 8 mg by mouth daily for up to 6 months.
- In children, it’s most often been used in doses of up to 3 mg by mouth daily for up to 3 months.
- Melatonin and its ubiquitous anticancer effects – Melatonin induces apoptosis and inhibits proliferation of numerous types of cancer cells.
- Melatonin: An important anticancer agent in colorectal cancer – “Many studies have focused on the beneficial effects of melatonin in colorectal cancers, such as induction of apoptosis, increased sensitivity to chemotherapy agents and radiotherapy, limiting cellular proliferation, migration, and invasion.”
- Melatonin for the prevention and treatment of cancer – “Melatonin could be an excellent candidate for the prevention and treatment of several cancers, such as breast cancer, prostate cancer, gastric cancer and colorectal cancer.”
Purpose
- Niacin (Vitamin B-3) is an essential B-group vitamin necessary for good health.
- Take 1 tablet daily with a meal.
This high potency tablet should be taken under doctor’s supervision.
- PROs Reported Dosing
- Children: between 2-16 milligrams daily, depending on age.
- Men: 16 milligrams daily.
- Women: 14 milligrams daily.
- Women (pregnant): 18 milligrams daily.
- Women (breastfeeding): 17 milligrams daily.
- Maximum daily intake for adults of all ages: 35 milligrams daily.
Purpose
- SUPPORT YOUR SKIN’S NATURAL DEFENSE MECHANISMS: Recommended by dermatologists. This valuable supplement is ideal for men, women, and aging individuals with sensitive or susceptible skin.
- HELP SUPPORT THE BODY’S NATURAL RESPONSE TO SKIN BLEMISHES: Nicotinamide can help support your body’s natural response to skin blemishes by supporting the skin’s natural ability to regenerate a smooth outer layer clear of blemishes, red spots, bumps, and warts. Preliminary clinical evidence suggests that nicotinamide may help support the body’s natural ability to control Polymorphous light eruption, a type of photosensitivity.
- SUPPORT YOUR ENERGY LEVELS: Do you suffer from fatigue and low energy levels? There are many, many reasons for this condition that affects so many. One reason could be inside your cells – when they don’t have the necessary nutrients to metabolize energy correctly. Nicotinamide may support the body’s natural mechanisms that improve energy production due to its role as a precursor of NAD, an important molecule involved in energy metabolism.
- Nicotinamide is well tolerated. Nicotinamide is a different form of vitamin B3 to nicotinic acid or niacin. Nicotinic acid commonly causes headaches, flushing and low blood pressure, but these side effects are generally not seen with nicotinamide. Preliminary evidence suggests that nicotinamide may support the body’s natural ability to support healthy joint mobility and comfort.
- PROs Reported Dosing
- The average daily requirement for vitamin B3 is 15-20mg.
- A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention – Oral use of 500mg 2x/day of nicotinamide resulted in a 23% lower rate of new nonmelanoma skin cancers after 12 months, compared with the control group that got a placebo. “Oral nicotinamide was safe and effective in reducing the rates of new nonmelanoma skin cancers and actinic keratoses in high-risk patients.”
- Prevention of non-melanoma skin cancers with nicotinamide in transplant recipients: a case-control study – 500mg/day of nicotinamide successfully shrank actinic keratosis in almost all patients, whereas almost all patients not taking it had increased growth; for some, the keratoses advanced to squamous cell carcinoma. “Nicotinamide appears to be effective in preventing and treating actinic keratosis.”
- PROs Reported Dosing
- 2 to 6 g/day in 2 to 3 divided doses.
- Methylsulfonylmethane (organic sulfur) induces apoptosis and decreases invasiveness of prostate cancer cells – MSM reduces migration and invasion of cancer cells, and causes apoptosis. “Considering the low overall body toxicity and insignificant side effects of MSM, its apoptosis-inducing properties might be used in PC treatment in the future.”
- Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells – MSM induces apoptosis in colon cancer cells.
- Methylsulfonylmethane inhibits HER2 expression through STAT5b in breast cancer cells – MSM decreases HER2 expression, making it particularly relevant for HER2+ breast cancer. “Therefore, we recommend the use of MSM as an inhibitor for the management of HER2-positive breast cancers.”
Organic Sulfur
- Polypodium Leucotomos Extract 240mg ~ 200 Capsules – No Additives ~ Naturetition Supplements
- The product does NOT contain: Preservatives, artificial coloring, artificial flavor, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
- Best Quality.
- Made in USA
- 100% Pure and Natural. Other Ingredients: Gelatin, Rice Powder.
- PROs Reported Dosing
- 240mg twice daily
- Polypodium leucotomos targets multiple aspects of oral carcinogenesis and it is a potential antitumor phytotherapy against tongue cancer growth “These results suggest that Polypodium leucotomos plays an important antitumor role in processes associated with oral carcinogenesis and may be a potential phytotherapeutic target for the prevention and/or adjuvant treatment of tongue cancer cells.”
- The combination of oral and topical photoprotection with a standardized Polypodium leucotomos extract is beneficial against actinic keratosis Actinic keratosis, a precursor to skin cancer, was reduced most in people who took Polypodium leucotomos orally and topically, moreso than the control group or the topical-only group. “Improvements in actinic keratosis and field cancerization parameters were greatest in the [topical and oral group], suggesting that topical and oral photoprotection improves the clinical and anatomical outcome compared to control conditions.”
- RESVERATROL FROM JAPANESE KNOTWEED – 1500mg Resveratrol is made from unrefined Japanese Knotweed which naturally contains 50% Trans-Resveratrol. Because this Resveratrol is organic, unrefined, and straight from the source, capsules will appear brown in color.
- MADE WITH BIOPERINE – Genex Resveratrol capsules are easy to swallow and have no weird tastes. Plus, our Resveratrol is made with BioPerine for better absorption!
- RESVERATROL FOR ALL – Each capsule in 1500mg bottle of Resveratrol contains 500mg Polygonum Cuspidatum (Japanese Knotweed) Root Extract. Take 1, 2, or 3 capsules per day to experience all the healthy aging benefits you need!
- FULLY STABILIZED – At Genex Formulas, we’ve designed our Resveratrol packaging for optimal storage. Each bottle is sturdy, durable, and opaque so you can trust your order will arrive safely and intact without compromising color. While we believe in our packaging, Genex Formulas does recommend you still store your Resveratrol in a cool, dry place, out of direct sunlight.
- PURCHASE WITH PEACE OF MIND – Resveratrol is made with global ingredients and bottled and tested at a GMP and NSF certified facility in Georgia, USA. Genex Formulas believes in your health, that’s why all our supplements are Non-GMO, Gluten Free, Vegan, and made with only the best quality ingredients.
- Liposomal Resveratrol and/or Carvedilol Attenuate Doxorubicin-Induced Cardiotoxicity by Modulating Inflammation, Oxidative Stress and S100A1 in Rats – Resveratrol reduced damage to the cardiovascular system caused by chemotherapy.
- Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin-induced cardiomyopathy in rats – More support for resveratrol reducing damage to the cardiovascular system caused by chemotherapy.
- Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice – The combination of liposomal curcumin and resveratrol reduced development of prostate cancer
- A VITAL NUTRIENT: Vitamin D supports healthy bones, teeth, muscle function, and a strong immune system. Many people may be deficient in this nutrient, making it even more important for overall health.*
- RECOMMENDED DOSE FOR KIDS & MOMS: 1000IU is the recommended amount of vitamin D3 for growing children and expecting mothers, but this product is intended to safely encourage calcium absorption and immune system strength in any user.
- SUNSHINE IN A BOTTLE: The Vitamin D Council recommends daily vitamin D supplementation for most adults to achieve and maintain optimal levels, regardless of weather or season.* NatureWise Vitamin D3 is all natural, non-GMO, and gluten free with no artificial additives, fillers or binders.
- PURE & NATURAL: These Vitamin D3 immune support and bone health supplements are gluten-free and non-GMO. Third party tested for purity and potency. Packaging may vary due to high demand, same great product and ingredients.
- UNCOMPROMISING QUALITY: All NatureWise supplements are Manufactured in USA-based facilities that comply to the strictest cGMP standards and undergo rigorous testing by third party labs to ensure the highest quality and purity.
- https://wholehealthoncology.com/node/51106
- https://wholehealthoncology.com/node/51290
- https://wholehealthoncology.com/node/50300
- https://wholehealthoncology.com/node/51327
- https://wholehealthoncology.com/node/51339
- https://wholehealthoncology.com/node/51281
- https://wholehealthoncology.com/node/51343
- https://wholehealthoncology.com/node/51302
- https://wholehealthoncology.com/node/51322
- Vitamin D and potential effects on cancers: a review – “Vitamin D is an essential nutrient for preventing malignancies and a complementary treatment for cancer through direct and indirect biochemical pathways.”
- Vitamin D regulates microbiome-dependent cancer immunity – “Vitamin D-induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival.”
- Vitamin D and Lung Cancer; Association, Prevention, and Treatment – “Epidemiological studies have reported that sufficient levels of VitD might be critical in the prevention of lung cancer.”
- Vitamin D in the Prevention and Treatment of Oral Cancer: A Scoping Review – “The current evidence suggests an association between vitamin D deficiency and an increased risk of oral cancer.”
*Disclaimer: Always consult with a physician or other qualified health-care professional before starting any new supplement program. We are not medical professionals, and any information pertaining to supplements or any other health and wellness modality is for educational purposes only and is not meant to treat, diagnose, or cure any health condition or disease. The interactions between supplements and drugs or between different supplements can be significant, and only a healthcare professional can evaluate your personal health needs and suggest the most beneficial supplements for you.
